571 NAPROXCINOD UNLIKE NAPROXEN INHIBITS EXPRESSION OF iNOS IN ACTIVATED MACROPHAGES IN VITRO
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چکیده
منابع مشابه
Semiquantitative RT-PCR analysis to assess the expression levels of iNOS in chicken macrophages
Abstract: iNOS is inducible by a variety of factors related to inflammation and referred to as inducible NOS(iNOS). It is regulated at the level of gene expression; once expressed, it produces NO at a high rate. iNOS gene-expression profiling is an important tool in understanding molecular markers of the responses of cells and tissues to external factors. In this article a semiquantitative reve...
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Naproxcinod shows significant advantages over naproxen in the mdx model of Duchenne Muscular Dystrophy
BACKGROUND In dystrophin-deficient muscles of Duchenne Muscular Dystrophy (DMD) patients and the mdx mouse model, nitric oxide (NO) signalling is impaired. Previous studies have shown that NO-donating drugs are beneficial in dystrophic mouse models. Recently, a long-term treatment (9 months) of mdx mice with naproxcinod, an NO-donating naproxen, has shown a significant improvement of the dystro...
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ژورنال
عنوان ژورنال: Osteoarthritis and Cartilage
سال: 2010
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(10)60598-5